BiochemistryOnline

Biomolecule eBooks

2011-11-28T18:04:00.000-08:00

I have uploaded the ebook for Biomolecules.

Bioinformatics Tools for Protein Structure Analysis and Visualisation

2011-11-08T19:12:00.000-08:00

If you need to study the primary, secondary, tertiary and quarternary stuructures of proteins visit this site .This site contains the collections of all the tools required to study a protein or a gene in detail.
For example if you have a amino acid sequence of a protein you can generate its 3-D structure using SWISS-MODEL - An automated knowledge-based protein modelling server. After generating one such structure you can study the details of the same molecule using Swiss-PdbViewer- A program to display, analyse and superimpose protein 3D structures.
Enjoy playing with Biomolecules.

Computational Biochemistry

2011-11-08T19:07:00.000-08:00

I am planning to include posts on "Computational Biochemistry" in future.
You can ask questions in this forum.

Arockya Santhai - Organic Food

2011-11-06T17:27:00.000-08:00

Organic foods are those that have been produced according to organic farming and processing standards. Organic farms do not use man-made fertilisers, pesticides and insecticides. Soil rotation, composting, planting complementary plants together enhance the growth of plants and result in food that is higher in vitamins and minerals and superior in taste.

Genetic engineering is not allowed in organic farming. Organic foods are processed with minimum processing and only a limited number of natural processing aids are approved.

http://www.arockyasanthai.com/

Scope of Biochemistry - Will I get a job ?

2011-10-05T09:36:00.000-07:00

While talking to many of the students and to some of my counterparts in the city, I noticed that many of them feel that there is no or little scope for biochemistry.   They are actually confusing between the words "Scope" and the "Jobs" after studying biochemistry.
Scope means the areas where one can get into and Job means getting into one.
After studying Biochemistry (BSc or MSc) you can get into the following areas ( with necessary extra skills):
1.   Diagnostic labs in hospitals ( you need to complete Medical Lab Technician course).
2.   Research and Development wings of industries manufacturing all the products that are used in our body, i.e., soaps, shampoos, tooth pastes, perfumes, talcs etc. because all these products involve the effectiveness in interacting with various biomolecules in our body. And this can be done effectively by a Biochemist only.
3.   e-Publishing in scientific journals and magazines.
4. ITeS - IT enabled services - this includes Medical Transcription, Medical Coding, Medical Billing.
5. Off late Online tutoring is getting more demand, especially from US, UK and other europeran countries.
If you like to set up your career in the area of biochemistry you can get into any of these.
For all of these areas you definitely require good communication, interpersonal skills, and basic computer knowledge.
Well, getting a Job depends on the vacancies and the expectations of those companies.
Cheers :)

Biochemistry Online - My New Webpage

2011-09-19T06:35:00.000-07:00

Dear All,
Thank you Samuel for the finding. I have corrected it and now you can visit my webpage.
Biochemistry Online - By Prof.PTS

Committed to Your Success
Sir

சிட்ரிக் அமில சுழற்சி TCA Cycle

2011-09-19T06:21:00.000-07:00

சிட்ரிக் அமிலம் கொழுப்புகள், புரதங்கள் மற்றும் கார்போஹைட்ரேட்டுகள் ஆகியவற்றின் கார்பன் டை ஆக்சைடு மற்றும் நீரை வழங்குவதற்கான உடலியக்கவியல் உயிர்வழியேற்றத்தில் ஈடுபடும் சேர்மங்களின் வரிசையில் ஒன்றாகும்.

இந்த வேதி வினைகளின் தொடர்களே, கிட்டத்தட்ட அனைத்து வளர்சிதைமாற்ற வினைகளுக்கும் மையமானதாகும். மேலும் உயர் உயிரினங்களில், உணவிலிருந்து பெறப்படும் ஆற்றலில் மூன்றில் இரண்டு பங்கின் மூலமும் இவ்வினைகளேயாகும். இந்தக் கண்டுபிடிப்புக்காக, ஹான்ஸ் அடால்ஃப் கிரெப்ஸ் 1953 ஆம் ஆண்டு உடலியக்கவியல் அல்லது மருத்துவத்திற்கான நோபல் பரிசைப் பெற்றார். இந்த தொடர் வினைகளுக்குப் பல பெயர்கள் வழங்கப்படுகின்றன, அவற்றில் சிட்ரிக் அமில சுழற்சி , கிரெப்ஸ் சுழற்சி மற்றும் டிரைகார்பாக்சிலிக் அமில சுழற்சி (TCA சுழற்சி ) ஆகியவையும் உள்ளடங்கும்).

கட்டற்ற கலைக்களஞ்சியமான விக்கிப்பீடியாவில் இருந்து. :)

தமிழ் பயோ கெமிஸ்ட்ரி

2011-09-01T04:04:00.000-07:00

தமிழ் மொழியில எழுதினா எப்படி இருக்கும்னு பார்க்கணும். நல்லா இருக்கு .
தமிழ்ல சில விவரங்களை தருகிறேன்
:)

Biochemistry Videos

2011-08-31T22:55:00.000-07:00

In this post, I am exposing two useful and informative videos related to Biochemistry.

1. NIH VideoCast broadcasts seminars, conferences and meetings live to a world-wide audience over the Internet as a real-time streaming video.
2. Journal of Visualized Experiments (JoVE) is a video journal for biological, medical, chemical and physical research indexed in PubMed.
:)

Rap song in Biochemistry

2011-08-23T19:31:00.001-07:00

For those who are interested in music and love RAP songs check this
video on a rap song in Biochemistry.

Paul Rothemund details DNA folding

2011-08-22T19:33:00.000-07:00

Watch this wonderful video on a newer perspective of DNA folding.
http://www.ted.com/talks/paul_rothemund_details_dna_folding.html

Biochemistry is difficult to study

2011-08-13T19:33:00.000-07:00

Many nutrition course students feel scared about biochemistry. Most of them, especially those from home science, and nutrition background feel worried about drawing structures.
There is no need to remember the structures of all the bio-molecules for students majoring in nutrition or nursing. If they can remember the names and the reactions it is sufficient. (What we call word equation - eg. glucose + ATP = glucose-6-phosphate) what they need to know is the fate of nutrients ingested; the location of the biochemical reaction of such nutrients inside a cell.
Learning the structures is important for students of pharmacology or pharmacy courses ( DPharm, BPharm, MPharm, MSc Pharmocology)
Biochemistry is not the only subject that is difficult ( if you feel it is difficult). And it doesn't mean that you pass in all other subjects and fail only in biochemistry. If such is the case, I can help anybody out of that. Just mail me.
:)

What is in a name?

2011-08-05T20:10:00.000-07:00

Can Biotechnology course be offered under a science stream ? I feel that the term technology is relevant only when offered under an engineering stream (BE or BTech). Therefore, the term Biotechnology is a misnomer in an arts and science college when offered as a BSc or MSc course.
I always get this doubt.
How can a technology degree be offered under a science stream ? this is also similar to MSc information technology course. Why should such "technology- labeled" degrees be offered under Science streams when the same is offered in engineering discipline also ?
There is something in the name " technology" . The name of the zoology course is changed to "Animal Biotechnology ..." and botany course is changed to "Plant Biology and Plant Biotechnology". There is more glamour for the name than the subject.
:)

Deos Biochemistry have future?

2011-08-02T19:01:00.000-07:00

Does Biochemistry have future ? Is it losing popularity ? Does it have scope for jobs? Many lifescience subjects have branched off from Biochemistry, viz., molecular biology, nutrition, biotechnology etc. Each of them have become a separate branch with much deeper studies done in them.
Therefore, the question is - Is it true that Biochemistry is becoming extinct with its sister subjects taking the center stage? (Something like evolution of animals)
:)

Biochemistry scares me ?!

2011-07-27T07:07:00.000-07:00

Is biochemistry losing its popularity among the prospective students?

I have a feeling that many of them are a bit scared about the subject - be they belong to nursing, pharmacy, nutrition, medicine etc.

Is this true ?

MCQs in Biochemistry

2011-07-12T20:03:00.000-07:00

This posts provides links to MCQs in biochemistry suitable for all entrance preparations.

1. Medical Entrance

2. Human Biochemistry , Mcqs , Quizzes and Postgraduation entrance preparation: 24 - biochemistry mcqs - 156 to 166

3. AIIMS MD biochemistry entrance

4. eBook collection on MCQs in Biochemistry

Committed to Your Success

Hangman in Biochemistry

2011-07-07T20:09:00.001-07:00

Try this Hangman

:)

Master Biochemistry in 24 hours.

2011-07-07T20:01:00.001-07:00

The content in this package (once you buy) is good for preparation especially just before exams. You can master biochemistry in 24 hours. It covers all the basic topics, with flash movies, cheat sheets, and quizzes. Each chapter is alloted 1 hour for studying and 24 chapters in 24 hours. either you can study one chapter a day or all of them in one week, depending on the pace and the time you have for your exams.

Master Biochemistry in 24 hours

Good Luck.

Online Biochemsitry Textbooks for Reading

2011-07-07T19:55:00.000-07:00

Read the Biochemistry Textbooks Online
Biochemistry - Mathews, van Holde, and Ahern
Textbook of Biochemsitry - Jeremy M Berg John L Tymoczko and Lubert Stryer
The Medical Biochemistry Page - M.W.King

Links on preparatory materials in Biochemistry

2011-07-07T19:37:00.001-07:00

This month, I am planning to introduce some useful & interesting ( to you also) websites on biochemistry. This post includes.
A List of Chapters with Links to Objectives, Key Words, Assignments, Practice Questions, and Other Help

Committed to Your Success.

The Inner Life of the Genome

2011-07-07T19:27:00.000-07:00

The way our genes are arrayed and move in the 3-D space of the cell nucleus turns out to profoundly influence how they function, in both health and disease

More details HERE.

The Visual Impact of Gossip - E. Anderson et al.

2011-06-16T18:37:00.000-07:00

Negative gossip about a person renders that person’s face more visible to the onlooker.

Read in detail . . .

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

2011-06-16T18:35:00.000-07:00

The adenosine monophosphate (AMP)–activated protein kinase (AMPK) regulates whole-body and cellular energy balance in response to energy demand and supply. AMPK is an αβγ heterotrimer activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK activation depends on phosphorylation of the α catalytic subunit on threonine-172 (Thr172) by kinases LKB1 or CaMKKβ, and this is promoted by AMP binding to the γ subunit. AMP sustains activity by inhibiting dephosphorylation of α-Thr172, whereas ATP promotes dephosphorylation. Adenosine diphosphate (ADP), like AMP, bound to γ sites 1 and 3 and stimulated α-Thr phosphorylation. However, in contrast to AMP, ADP did not directly activate phosphorylated AMPK. In this way, both ADP/ATP and AMP/ATP ratios contribute to AMPK regulation.

Movie on Actin filaments in action

2011-05-09T19:51:00.000-07:00

Scientists at Yale University and in Grenoble France have succeeded in creating a movie showing the breakup of actin filaments, the thread-like structures inside cells that are crucial to their movement, maintenance and division.
Actin Filaments, Cellular 'Workhorses,' Caught in Action

How Molecules Get to the Right Place at the Right Time

2011-04-26T20:45:00.000-07:00

In a multicellular organism, different cells fulfill a range of diversified functions. Often such specialization depends on the delivery of molecular goods to distinct places within a cell. It ensures that particular functions only occur at defined cellular sites. This establishment of intracellular asymmetry in the otherwise fluid environment of the cell cytoplasm requires active transport processes. Messenger RNAs (mRNA) represent an especially important type of freight.
All cells containing a nucleus also possess a cytoskeleton made up of filamentous protein strands that course through intracellular space like a rail network. Motor proteins "walk" along two types of these strands, called actin filaments and microtubules. On their way, they can carry different types of freight like membrane vesicles, messenger RNAs, proteins and even whole organelles. Disruption of these networks can cause chaos and may result in cell death. The motor proteins must recognize and bind to the correct fiber system and to the appropriate cargo. For transport of freight, molecular motors interact with a plethora of accessory factors to form large transport complexes.

Journal Reference:

Marisa Müller, Roland Gerhard Heym, Andreas Mayer, Katharina Kramer, Maria Schmid, Patrick Cramer, Henning Urlaub, Ralf-Peter Jansen, Dierk Niessing. A Cytoplasmic Complex Mediates Specific mRNA Recognition and Localization in Yeast. PLoS Biology, 2011; 9 (4): e1000611 DOI: 10.1371/journal.pbio.1000611

Discovery Identifies Elaborate G-Protein Network in Plants

2011-04-26T20:39:00.000-07:00

The most elaborate heterotrimeric G-protein network known to date in the plant kingdom has been identified by Dr. Sona Pandey, principal investigator at the Danforth Plant Science Center. The results of this research are published in the recent article, "An elaborate heterotirmeric G-protein family from soybean expands the diversity of G-protein networks," in the New Phytologist.

Journal Reference:

Naveen C. Bisht, Joseph M. Jez, Sona Pandey. An elaborate heterotrimeric G-protein family from soybean expands the diversity of plant G-protein networks. New Phytologist, 2011; 190 (1): 35 DOI: 10.1111/j.1469-8137.2010.03581.x

Nicotine Does Not Promote Lung Cancer Growth in Mouse Models, Study Finds

2011-04-17T02:43:00.000-07:00

Nicotine at doses similar to those found in most nicotine replacements therapies did not increase lung cancer tumor incidence, frequency or size, according to results of a mouse study presented at the AACR 102nd Annual Meeting 2011, held in Orlando, Florida April 2-6.
Read on . . . .

Enzyme crucial to DNA replication may provide potent anti-cancer drug target

2011-04-17T02:33:00.000-07:00

An enzyme essential for DNA replication and repair in humans works in a way that might be exploited as anti-cancer therapy, say researchers.
Read on . . .

Protein Could Be New Target to Reduce Damage After Heart Attack

2011-03-31T08:28:00.000-07:00

Scientists have identified a protein that plays a key role in debilitating changes that occur in the heart after a heart attack, according to research reported in Circulation Research: Journal of the American Heart Association
Reference:
Fatih Arslan, Mirjam B. Smeets, Paul W. Riem Vis, Jacco C. Karper, Paul H. Quax, Lennart G. Bongartz, John H. Peters, Imo E. Hoefer, Pieter A. Doevendans, Gerard Pasterkamp, and Dominique P. de Kleijn. Lack of Fibronectin-EDA Promotes Survival and Prevents Adverse Remodeling and Heart Function Deterioration After Myocardial Infarction. Circ. Res.,, Feb 2011

Cell Pathway Key to Insulin Resistance in Type 2 Diabetes Illuminated

2011-03-31T08:26:00.000-07:00

A research team, led by La Jolla Institute scientist Joel Linden, Ph.D., has shed new light on the problem of insulin resistance, and identified the key participants in a molecular pathway that holds therapeutic promise for reducing the severity of type 2 diabetes.
Read on. .
R. A. Figler, G. Wang, S. Srinivasan, D. Y. Jung, Z. Zhang, J. S. Pankow, K. Ravid, B. Fredholm, C. C. Hedrick, S. S. Rich, J. K. Kim, K. F. LaNoue, J. Linden. Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans. Diabetes, 2011; 60 (2): 669

Maternal Fructose Intake Impacts Female and Male Fetuses Differently

2011-03-31T08:21:00.000-07:00

A recent study accepted for publication in Endocrinology, a publication of The Endocrine Society, reports for the first time that maternal fructose intake during pregnancy results in sex-specific changes in fetal and neonatal endocrinology.
Read on . .

Scientists Find a New Way Insulin-Producing Cells Die

2011-03-31T08:18:00.000-07:00

The death of insulin-producing beta cells in the pancreas is a core defect in diabetes. Scientists in Italy and Texas now have discovered a new way that these cells die -- by toxic imbalance of a molecule secreted by other pancreatic cells.
Read on. . . .
http://www.sciencedaily.com/releases/2011/02/110225122912.htm

Collisions of protein machines cause DNA replication derailment

2011-03-19T20:03:00.000-07:00

The Traffic jam created by the movement of proteins inside a cell affects the DNA replication.
Read on . . .

Protein identified that serves as a switch in a key pathway of programmed cell death

2011-03-19T20:01:00.001-07:00

Protein identified that serves as a switch

How much can a cell uptake?

2011-03-19T19:58:00.000-07:00

How much can a cell uptake?

Novel mechanism for control of gene expression revealed

2011-03-19T19:54:00.000-07:00

ScienceDaily (2011-03-06) -- Scientists have recently discovered a novel, evolutionarily conserved mechanism for the regulation of gene expression. Normal cell growth, embryonic development, and responses to stress, require proper spatial and temporal control of gene expression. Studies on control of transcription (RNA biosynthesis) are typically centered on understanding how the RNA polymerase is recruited to the promoter, the control region of a gene. However, new work has revealed the existence of a second level of control in a yeast model system.

Enzyme enhances, erases long-term memories in rats; Can restore even old, fading memories, say scientists

2011-03-19T19:52:00.000-07:00

ScienceDaily (2011-03-07) -- Even long after it is formed, a memory in rats can be enhanced or erased by increasing or decreasing the activity of a brain enzyme. For the first time, a study in behaving animals with functioning brains has found that a single molecule, PKMzeta, is both necessary and sufficient for maintaining long-term memory.

http://www.sciencedaily.com/releases/2011/03/110304092111.htm#

web page on MSc dissertations

2007-11-27T06:47:00.000-08:00

Dear students,

I have reconstructed the webpage for MSc dissertation guidelines take a look at it

Dissertation

Comitted to your success
The Biochemistry Survival Coach
Prof.PTS

Micro waved water - a MUST read

2007-01-05T05:10:00.000-08:00

Micro waved water - a MUST read

A 26-year old decided to have a cup of coffee. He took a cup of water and

put it in the microwave to heat it up (something that he had done numerous

times before). I am not sure how long he set the timer for, but he told me

he wanted to bring the water to a boil. When the timer shut the oven off,

he removed the cup from the oven. As he looked into the cup, he noted that

the water was not boiling, but instantly the water in the cup "blew up"

into his face. The cup remained intact until he threw it out of his hand

but all the water had flown out into his face due to the build up of

energy. His whole face is blistered and he has 1st and 2nd degree burns to

his face, which may leave scarring. He also may have lost partial sight in

his left eye. While at the hospital, the doctor who was attending to him

stated that this is fairly common occurrence and water (alone) should

never be heated in a microwave oven. If water is heated in this manner,

something should be placed in the cup to diffuse the energy such as: a

wooden stir stick, tea bag, etc. It is however a much safer choice to boil

the water in a teakettle.

General Electric's (GE) response:

Thanks for contacting us. I will be happy to assist you. The e-mail that

you received is correct. Microwaved water and other liquids do not always

bubble when they reach the boiling point. They can actually get

superheated and not bubble at all. The superheated liquid will bubble up

out of the cup when it is moved or when something like a spoon or tea bag

is put into it. To prevent this from happening and causing injury, do not

heat any liquid for more than two minutes per cup. After heating, let the

cup stand in the microwave for thirty seconds before moving it or adding

anything into it.

If you pass this on ... you could very well save someone from a lot of

pain and suffering.

ProfPTS

http://profpts.googlepages.com

http://www.biochemistryonline.4t.com

Matter ?!

2006-09-28T22:49:00.000-07:00

How do we define "matter" ?

is it a particle, substance, atom, electrons or protons, wave, force , energy ?
but we know the properties of it. it occupies space, has weight (mass !), cannot be created or destroyed but can be converted from one form to another.

when we define something, we have to say what it is first then go on to say about its properties ?

any thougths in these lines ?

it is a different matter....Oh !

2006-09-28T02:56:00.000-07:00

I have just created a Blog for Biochemistry students . More to come in upcoming days. In the mean time ccheck out my webpage at

profpts.googlepages.com/

For interactive tutorials

http://www.wiley.com/legacy/college/boyer/0470003790/index.htm

pts