All cells containing a nucleus also possess a cytoskeleton made up of filamentous protein strands that course through intracellular space like a rail network. Motor proteins "walk" along two types of these strands, called actin filaments and microtubules. On their way, they can carry different types of freight like membrane vesicles, messenger RNAs, proteins and even whole organelles. Disruption of these networks can cause chaos and may result in cell death. The motor proteins must recognize and bind to the correct fiber system and to the appropriate cargo. For transport of freight, molecular motors interact with a plethora of accessory factors to form large transport complexes.
- Marisa Müller, Roland Gerhard Heym, Andreas Mayer, Katharina Kramer, Maria Schmid, Patrick Cramer, Henning Urlaub, Ralf-Peter Jansen, Dierk Niessing. A Cytoplasmic Complex Mediates Specific mRNA Recognition and Localization in Yeast. PLoS Biology, 2011; 9 (4): e1000611 DOI: 10.1371/journal.pbio.1000611