Mar 31, 2011

Protein Could Be New Target to Reduce Damage After Heart Attack

Scientists have identified a protein that plays a key role in debilitating changes that occur in the heart after a heart attack, according to research reported in Circulation Research: Journal of the American Heart Association
Fatih Arslan, Mirjam B. Smeets, Paul W. Riem Vis, Jacco C. Karper, Paul H. Quax, Lennart G. Bongartz, John H. Peters, Imo E. Hoefer, Pieter A. Doevendans, Gerard Pasterkamp, and Dominique P. de Kleijn. Lack of Fibronectin-EDA Promotes Survival and Prevents Adverse Remodeling and Heart Function Deterioration After Myocardial Infarction. Circ. Res.,, Feb 2011

Cell Pathway Key to Insulin Resistance in Type 2 Diabetes Illuminated

A research team, led by La Jolla Institute scientist Joel Linden, Ph.D., has shed new light on the problem of insulin resistance, and identified the key participants in a molecular pathway that holds therapeutic promise for reducing the severity of type 2 diabetes.
Read on. .
R. A. Figler, G. Wang, S. Srinivasan, D. Y. Jung, Z. Zhang, J. S. Pankow, K. Ravid, B. Fredholm, C. C. Hedrick, S. S. Rich, J. K. Kim, K. F. LaNoue, J. Linden. Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans. Diabetes, 2011; 60 (2): 669

Maternal Fructose Intake Impacts Female and Male Fetuses Differently

A recent study accepted for publication in Endocrinology, a publication of The Endocrine Society, reports for the first time that maternal fructose intake during pregnancy results in sex-specific changes in fetal and neonatal endocrinology.
Read on . .

Scientists Find a New Way Insulin-Producing Cells Die

The death of insulin-producing beta cells in the pancreas is a core defect in diabetes. Scientists in Italy and Texas now have discovered a new way that these cells die -- by toxic imbalance of a molecule secreted by other pancreatic cells.
Read on. . . .

Mar 19, 2011

Collisions of protein machines cause DNA replication derailment

The Traffic jam created by the movement of proteins inside a cell affects the DNA replication.
Read on . . .

Protein identified that serves as a switch in a key pathway of programmed cell death

Protein identified that serves as a switch

How much can a cell uptake?

How much can a cell uptake?

Novel mechanism for control of gene expression revealed

ScienceDaily (2011-03-06) -- Scientists have recently discovered a novel, evolutionarily conserved mechanism for the regulation of gene expression. Normal cell growth, embryonic development, and responses to stress, require proper spatial and temporal control of gene expression. Studies on control of transcription (RNA biosynthesis) are typically centered on understanding how the RNA polymerase is recruited to the promoter, the control region of a gene. However, new work has revealed the existence of a second level of control in a yeast model system.

Enzyme enhances, erases long-term memories in rats; Can restore even old, fading memories, say scientists

ScienceDaily (2011-03-07) -- Even long after it is formed, a memory in rats can be enhanced or erased by increasing or decreasing the activity of a brain enzyme. For the first time, a study in behaving animals with functioning brains has found that a single molecule, PKMzeta, is both necessary and sufficient for maintaining long-term memory.