Distributing the knowledge of Biochemistry to my students who continue to teach me
Sign My Guest Book
Aug 2, 2011
Deos Biochemistry have future?
Therefore, the question is - Is it true that Biochemistry is becoming extinct with its sister subjects taking the center stage? (Something like evolution of animals)
:)
Jul 27, 2011
Biochemistry scares me ?!
Jul 12, 2011
MCQs in Biochemistry
Jul 7, 2011
Master Biochemistry in 24 hours.
Master Biochemistry in 24 hours
Good Luck.
Links on preparatory materials in Biochemistry
A List of Chapters with Links to Objectives, Key Words, Assignments, Practice Questions, and Other Help
Committed to Your Success.
The Inner Life of the Genome
The way our genes are arrayed and move in the 3-D space of the cell nucleus turns out to profoundly influence how they function, in both health and disease
Jun 16, 2011
The Visual Impact of Gossip - E. Anderson et al.
AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
The adenosine monophosphate (AMP)–activated protein kinase (AMPK) regulates whole-body and cellular energy balance in response to energy demand and supply. AMPK is an αβγ heterotrimer activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK activation depends on phosphorylation of the α catalytic subunit on threonine-172 (Thr172) by kinases LKB1 or CaMKKβ, and this is promoted by AMP binding to the γ subunit. AMP sustains activity by inhibiting dephosphorylation of α-Thr172, whereas ATP promotes dephosphorylation. Adenosine diphosphate (ADP), like AMP, bound to γ sites 1 and 3 and stimulated α-Thr phosphorylation. However, in contrast to AMP, ADP did not directly activate phosphorylated AMPK. In this way, both ADP/ATP and AMP/ATP ratios contribute to AMPK regulation.